Download PDF by Carl Eisdorfer PhD MD: Annual Review of Gerontology and Geriatrics, Volume 3, 1982:

By Carl Eisdorfer PhD MD

Long island 1982 Springer. 8vo, 436pp., index, unique gilt published hardcover. VG, tiny chip on entrance, no DJ.

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Extra info for Annual Review of Gerontology and Geriatrics, Volume 3, 1982: Clinical, Behavioral and Social Issues

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Parents of such patients are obligatory carriers and have normal or almost normal methemoglobin levels under usual living conditions. However, when challenged by methemoglobin-inducing drugs, such carriers have relatively insufficient enzyme to reduce methemoglobin, and methemoglobinemic cyanosis results. Conceptu- PHARMACOGENETICS 43 ally, this situation is a very important type of drug reaction, since simple arithmetic indicates that even for a rare autosomal recessive disease there are many carriers in the population.

W. 1932. Anti-SRBC aggultination with age. Am. J. Med. Sci. 183:90. , and Van Zwieten, M. J. 1980. Idiopathic paraproteinemia. III. Increased frequency of paraproteinemia in thymectomized aging C57BL/KaLwRij and CBA/BrRij mice. /. Immunol. 125:31. Roberts-Thompson, I. , Whittingham, S. , and MacKay, T. R. 1974. Ageing, immune response and mortality. Lancet 2:368. Rosenstein, M. , and Strausser, H. R. 1980. Macrophage-induced T-cell mitogen suppression with age. J. Reticuloendothel. Soc. 27:159.

Thus, actual lean body mass is reduced as a proportion of total body weight. Drugs which are distributed mainly in body water or lean body mass will have higher blood levels in the elderly if the dose is based upon body weight or surface area. The same phenomenon affects measures of renal function (Rowe, 1981). The doses of many drugs excreted primarily by the kidneys are adjusted routinely to compensate for decrease in renal function, particularly digitalis preparations and aminoglycoside antibiotics.

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