New PDF release: Annual Review of Gerontology and Geriatrics, Volume 4, 1984

By Carl Eisdorfer PhD MD

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Additional info for Annual Review of Gerontology and Geriatrics, Volume 4, 1984

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Perspectives on Prevention and Treatment of Cancer in the Elderly. Raven Press, New York, 1983. , et al. Surveillance, epidemiology, and end results: Incidence and mortality data, 1973-77. Natl. Cancer Inst. Monograph 57:June 1981. , and ROBERT J. D. DEPARTMENTS OF MEDICINE AND BIOCHEMISTRY UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES GERIATRIC RESEARCH EDUCATION AND CLINICAL CENTER VETERANS ADMINISTRATION MEDICAL CENTER LITTLE ROCK, ARKANSAS After maturity physiologic decline occurs in virtually all systems (1).

Hopefully, future health policy strategies will specifically address the questions of benefit versus risk for all these screening procedures in the elderly. REFERENCES Aging and cancer (editorial). Lancet 7:131, 1976. S. Modifying effect of aging on chemical carcinogenesis. A revue. Mech. Ageing Dev. 75:399, 1981. , et al. Are the elderly predisposed to toxicity from cancer chemotherapy? Cancer Clin. Trials 5:369, 1980. P. Clinical trials and drug toxicity in the elderly. Cancer 52: 1986, 1983.

GENOMIC PLASTICITY IN AGING HUMAN CELLS 47 sequences but it was clear at low Cot values that significant differences between early and late-passage DNA were reproducible. Other studies (34) reveal that three other discrete highly repetitive sequences characterized as bands of 45, 110, and 175 base pairs generated by the restriction endonuclease Msp I were also found to diminish in the same three normal strains of fibroblasts at late passage. Alternative explanations for the apparent loss of highly reiterated DNA sequences during aging in vitro were carefully considered.

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