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This atlas includes greater than seven hundred illustrations that the authors have amassed through the years in addition to references and data concerning lately built drug periods, together with biologics. it's a helpful bench reference for training pathologists and will even be used as a reference textual content by way of different specialists from similar fields. The atlas is organised into diverse chapters in accordance with systemic pathology. each one bankruptcy has illustrations with legends, and the atlas comprises a few infrequent examples of detailed lesions chanced on in the course of toxicity reports over many years.
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Extra resources for Atlas of Toxicological Pathology
34. Westwood FR, Iswaran TJ, Greaves P. Pathologic changes in blood vessels following administration of an inotropic vasodilator (ICI 153,110) to the rat. Fundam Appl Toxicol. 1990;14: 797–809. 16. Herman EH, Knapton A, Rosen E, Thompson K, Rosenzweig B, Estis J, et al. A multifaceted evaluation of imatinib-induced cardiotoxicity in the rat. Toxicol Pathol. 2011;39:1091–106. 35. Weaver JL, Zhang J, Knapton A, Miller T, Espandiari P, Smith R, et al. Early events in vascular injury in the rat induced by the phosphodiesterase IV inhibitor SCH 351591.
Eosinophilic inclusions also may appear in the FIGURE 2-2. Goblet cell hyperplasia of the nasal turbinates from a rat given a β-adrenergic agent. The respiratory epithelium lining the turbinates is composed mainly of hypertrophic goblet cells. H&E. epithelium of the submucosal glands and their ducts (Fig. 4). They may be located in any area of the cell, often becoming very large and displacing the nuclei. Ultrastructurally, they appear as membrane-bound ellipsoid bodies containing a homogenous electron-dense matrix.
The olfactory epithelium along the dorsal meatus and turbinates appears unevenly thinner, with cell loss and/or disorganisation in many areas. H&E. 24 Atlas of Toxicological Pathology a b FIGURE 2-17. Reflux-associated changes in the nasal turbinates of a mouse given a pharmaceutical by gavage. Eosinophilic fluid containing inflammatory cells is seen in the dorsolateral aspects of the nasal cavity, between the ethmoid turbinates. Exudate in the nasopharynx indicates the likely pathogenesis. These are the areas often affected in reflux.