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By P. N. Bennett MD FRCP, Morris J. Brown MSc MD FRCP

Univ. of bathtub, united kingdom. Textbook presents the foundations of pharmacology, how medicinal drugs get into the physique, how medicines produce their results, what occurs within the physique, and the way the healing impact is classified. medicinal drugs are mentioned and arranged in response to physique method. makes a speciality of evidence-based drug treatment. past variation: c1997. Softcover.

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Some 35% of the physically ill and 40% or more of the mentally ill respond to placebos. Placebo reaction is an inconstant attribute; a person may respond at one time in one situation and not at another time under different conditions. There is some consistency in the type of person who tends to react to any therapeutic intervention. In one study on medical students, psychological tests revealed that those who reacted to a placebo tended to be extraverted, sociable, less dominant, less selfconfident, more appreciative of their teaching, more aware of their autonomic functions and more neurotic than their colleagues who did not react to a placebo under the particular conditions of the experiment.

Generic substitution, where a generic formulation (p. 85) is substituted (by a pharmacist) for the proprietary formulation prescribed by the doctor. 2. Therapeutic substitution, where a drug of different chemical structure is substituted for the drug prescribed by the doctor. The substitute is of the same chemical class and is deemed to have similar pharmacological properties and to give similar therapeutic benefit. Therapeutic substitution is a particularly controversial matter where it is done without consulting the prescriber, and legal issues may be raised in the event of adverse therapeutic outcome.

Manufacturers should aim at one or two doses per day (not more), and this is generally best achieved with drugs having relatively long biological effect tl/2, or where the biological effect il/2 is short, by using sustained-release formulations. Discontinuation syndrome (recurrence of disease, rebound, or withdrawal syndrome) may occur due to a variety of mechanisms (see Index). Placebo medicines A placebo55 is any component of therapy that is without specific biological activity for the condition being treated.

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