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Additional info for Cytokines Engaged in Antiviral Action, Macrophage Activation, Angiogenesis, and Regulation of Cell Growth and Differentiation

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28 Principles of Clinical Pharmacology Mechanisms of Transcapillary Exchange At this time, the physiological basis for the transfer of drugs and other compounds between compartments can only be inferred for mammillary systems in which the central compartment represents intravascular space and intercompartmental clearance can be equated with transcapillary exchange. In the case of inulin and urea, intercompartmental clearance (CLI ) can be analyzed in terms of the rate of blood flow (Q) through exchanging capillary beds and the permeability coefficient–surface area product (P · S) characterizing diffusion through capillary fenestrae (primarily in splanchnic capillary beds) or small pores (primarily in somatic capillary beds).

Atkinson AJ Jr. Individualization of anticonvulsant therapy. Med Clin North Am 1974;58:1037–49. 17. Rowland M, Tozer TN. Clinical pharmacokinetics: Concepts and applications. 3rd ed. Baltimore: Lea & Febiger, 1994. 18. Gaddum JH. Repeated doses of drugs. Nature 1944;153:494. 19. Van Valkenberg ME. The Laplace transformation. In: Network analysis. Englewood Cliffs (NJ): PrenticeHall;1964. p. 159–81. STUDY PROBLEMS Select the one lettered answer or statement completion that is BEST. It may be helpful to carry out dimensional analysis by including units in your calculations.

Time curve is likely to be observed only when the drug is administered by rapid intravenous injection and blood samples are obtained frequently in the immediate postinjection period. The central compartment of a pharmacokinetic model usually is the only one that is directly accessible to sampling. When attempting to identify this compartment as intravascular space, the erythrocyte/plasma partition ratio must be incorporated in comparisons of central compartment volume with expected blood volume if plasma levels, rather than whole blood levels, are used for pharmacokinetic analysis.

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