By Dorothy Rosenthal, Stephen S. Raab
The necessities in Cytopathology sequence publishes generously illustrated and easy courses with over a hundred complete colour pictures that illustrate ideas and perform in Cytopathology for pathologists and clinicians. Cytologic Detection of Urothelial Lesions via Dorothy L. Rosenthal, MD and Stephen S. Raab, MD is the second one quantity within the sequence. This quantity will current an easy method of facing mobile samples from the urinary tract.
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Extra resources for Cytologic Detection of urothelial lesions
33). This is generally encountered when dealing with a sample from a patient with a low grade lesion, especially those called “low malignant potential” (LMP), or in the presence of severe inﬂammation, calculus disease, or following chemotherapy. Emerging ancillary tests, beyond the scope of this volume, will potentially bring clarity to these frustrating lesions. Note that “dysplasia” is not included as a diagnostic choice. In the authors’ experience, cytologic samples rarely contain cells from a dysplasia unless they have been mechanically dislodged.
Compare the infected cell with the adjacent benign urothelial cell. (600x). 44 2. 22. Herpes Simplex Infection—voided urine: A cell with herpetic viral inclusions is seen in the center ﬁeld admixed with blood, benign urothelial cells and acute inﬂammation. The herpetic cell exhibits a multilobated nucleus and a relatively low nuclear to cytoplasmic ratio. The cytoplasm appears homogeneous. 23. Herpes Simplex Infection—urethral brushing: Intranuclear inclusions, multinucleation and nuclear molding typify Herpes infection anywhere in the body.
The cytoplasm is granular and there is an absence of cytoplasmic homogeneity. Nuclear overlap may be seen in catheterized specimens and in this case, the nuclei vary in size, although for the most part are round in shape. (600x) 30 2. 8. Normal Umbrella Cells—bladder washing: Instrumentation will usually produce tissue fragments. The distinct cellular outlines, frothy cytoplasm and relatively round, uniform nuclei testify to their benign nature. 9. Normal Cells: Bladder washing can produce sheets of normal urothelial cells as well as single umbrella cells.