By Uwe Rudolph
This new quantity of Advances in Pharmacology provides the variety and features of GABA Receptors. the quantity seems at study played some time past twenty years which has printed particular physiological and pharmacological services of person GABAA receptor subtypes, delivering novel possibilities for drug development.
- Contributions from the easiest authors within the field
- An crucial source for pharmacologists, immunologists, and biochemists
Read or Download Diversity and Functions of GABA Receptors: A Tribute to Hanns Möhler, Part A PDF
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Additional resources for Diversity and Functions of GABA Receptors: A Tribute to Hanns Möhler, Part A
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The effectiveness of the extremely low benzodiazepine dose may be due to two factors: the degree of pharmacological inhibition required for rebalancing may be small, as shown in the Rett mouse model (a 30–40% reduction in GABA release is sufficient to induce Rett-like symptoms), or a pathological deficit of GABA neurons may trigger a compensatory upregulation of GABAA receptors, increasing the sensitivity of the system to benzodiazepines. 6. Role of GABAA receptor subtypes It is reassuring that α1 GABAA receptors, which are associated with sedative actions of these drugs, do not appear to be required for reversing the social interaction deficit, as shown by the effectiveness of L-838417, an α2,α3,α5 partial agonist, in the BTBR model.