By Robert G. Forman, Susanna K. Gilmour-White, Nathalie H. Forman
This special resource of reference presents a complete consultant to the antagonistic side-effects of many often pharmaceuticals on fertility and sexual health and wellbeing. greater than one hundred fifty medicinal drugs are indexed during this compilation, and the proof linking them with infertility and sexual disorder is punctiliously reviewed. the amount is designed to supply a swift resource of connection with alert medical professionals and pharmacists to those harmful side-effects. the quantity additionally comprises an introductory account of the reproductive approach and a evaluation of the mechanisms in which those medications can intervene or inhibit copy. one other vital subject matter of the quantity is the impression of social and leisure medicinal drugs and environmental brokers on reproductive overall healthiness.
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Extra info for Drug-Induced Infertility and Sexual Dysfunction
This patient developed an anticholinergic crisis on cyproheptadine, associated with tachycardia, hypertension and a fever. Although a serotonin blocker, cyproheptadine also has weak anticholinergic activity, which was thought to act synergistically with desipramine to induce the crisis (Pontius, 1988). Another potential danger is that the addition of cyproheptadine reverses not only the sexual dysfunction but also the therapeutic benefit, causing a relapse of depressive symptoms. This is particularly true for antidepressants that act as serotonin-reuptake inhibitors.
The manufacturer's data sheet lists impotence and failure of ejaculation as possible side effects, but this may be related to the sedative effects of this drug. Calcium-channel blockers Calcium antagonists such as nifedipine and verapamil decrease coronary and vascular smooth muscle tone by blocking calcium influx into cells. There are few clinical reports of this class of drug being associated with sexual dysfunction. A report described three cases of impotence in 14 patients treated for arrhythmias and angina with verapamil and digoxin.
Decreased peripheral resistance has been suggested, but 20 Antihypertensive therapy sexual side effects have not been reported with vasodilators that have a similar mode of action. It has also been proposed that it may be the result of a direct effect of thiazides on smooth muscle or by interference with catecholamine responsiveness. Spironolactone This potassium-sparing diuretic has been associated with a variety of sexual side effects. Dose-dependent gynaecomastia is well recognised and occurred in 100% of patients treated with 400 mg/day (used to differentiate primary from secondary hyperaldosteronism); 30% also developed impotence.