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Azole Antifungals [fluconazole, itraconazole, ketoconazole] Increased effects of corticosteroid. Decrease corticosteroid dose if necessary. MEDFACTS POCKET GUIDE OF DRUG INTERACTIONS / 41 DRUG INTERACTING DRUG Estrogens [chlorotrianisene, conjugated estrogens, diethylstilbesterol, esterified estrogens, estradiol, estrone, estropipate, ethinyl estradiol, quinestrol] POTENTIAL EFFECT Increased effects of corticosteroid. MANAGEMENT Decrease corticosteroid dose if necessary. DIURETICS Loop Diuretics Loop Diuretics-class Bumetanide, Ethacrynic Acid, Furosemide, Torsemide Aminoglycosides, see Antimicrobial Agents (Antibacterial Antibiotics) Cisplatin Increased risk of ototoxicity.

Decrease cyclosporine dose if necessary. Azole Antifungals [fluconazole, itraconazole, ketoconazole] Increased concentrations of cyclosporine. Monitor cyclosporine concentrations and for signs/symptoms of toxicity. Adjust cyclosporine dose as needed when starting or stopping azole antifungal. Carbamazepine Decreased concentrations of cyclosporine. Monitor cyclosporine concentrations and for signs/symptoms of organ rejection. Increase cyclosporine dose if necessary. 54 / MEDFACTS POCKET GUIDE OF DRUG INTERACTIONS DRUG INTERACTING DRUG POTENTIAL EFFECT MANAGEMENT Carvedilol Increased concentrations of cyclosporine.

Haloperidol, see Sedatives/Hypnotics/Agents used in Psychiatry (Antipsychotic Agents) Iodide Salts [calcium iodide, hydrogen iodide, iodide, iodinated glycerol, iodine, potassium iodide, sodium iodide] Increased risk of hypothyroidism. Avoid combination if possible. Otherwise, adminsiter thyroid hormone if necessary NSAIDs [diclofenac, ibuprofen, indomethacin, ketorolac, meloxicam, naproxen, piroxicam, sulindac] Increased concentrations of lithium. Monitor lithium concentrations. Adjust lithium dose as needed when starting or stopping NSAID.

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