By Ian Eardley, Peter Whelan, Roger Kirby, Anthony Schaeffer
A operating consultant to using medications within the therapy of urological diseaseThe content material is prepared in order that the busy urologist can pass fast and simply to the proper sectionCoverage of therapy is evidence-basedIt is the single present e-book on drug remedy in urologyGreat strides were made within the knowing of the clinical foundation of urological stipulations and this has allowed the improvement of gear for a wide selection of urological disorders.This ebook offers urologists with a operating consultant to the quickly becoming armoury of gear on hand to them.
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Repens provided no additional beneﬁt. Pygeum africanum Pygeum africanum or the African plum is believed to act by modulating growth factor–induced cell growth and proliferation . Its effects on the bladder were elegantly demonstrated by Levine et al. , who showed in a rabbit model that the increases in the bladder wall mass and decreases in compliance caused by partial outﬂow obstruction could be reduced by treatment with P. africanum. Clinical trials, although numerous, are largely inadequate and none have met the criteria of the International Consultation on BPH for assessing treatment in men with LUTS .
Eur Urol 1999; 36(1): 1–13. 17 Kirby RS. Doxazosin in benign prostatic hyperplasia: effects on blood pressure and urinary ﬂow in normotensive and hypertensive men. Urology 1995; 46(2): 182–6. 18 McConnell JD, Bruskewitz R, Walsh P, Andriole G, Lieber M, Holtgrewe HL et al. The effect of ﬁnasteride on the risk of acute urinary retention and the need for surgical treatment among men with benign prostatic hyperplasia. Finasteride Long-Term Efﬁcacy and Safety Study Group. N Engl J Med 1998; 338(9): 557–63.
50 Chapple C, Rechberger T, Al-Shukri S, Meffan P, Everaert K, Ridder A. Results of a randomized phase 3 study comparing solifenacin succinate with tolterodine and placebo in patients with symptomatic overactive bladder. Neurourol Urodyn 2003; 22(5): 534–5. 51 Mattiasson A, Ekstro¨m B, Andersson KE. Effects of intravesical instillation of verapamil in patients with detrusor hyperactivity. J Urol 1989; 141(1): 174–7. 52 Fey TA, Gopalakrishnan M, Strake JG et al. Effects of ATP-sensitive Kþ channel openers and tolterodine on involuntary bladder contractions in a pig model of partial bladder outlet obstruction.