New PDF release: Evaluating Chemical and Other Agent Exposures for

By Subcommittee on Reproductive and Developmental Toxicity, Committee on Toxicology, Board on Environmental Studies and Toxicology, National Research Council, Commission on Life Sciences

Record of the Subcommittee on Reproductive and Developmental Toxicology of suggested ways that may be used to judge chemical compounds and actual brokers for his or her strength to reason reproductive and developmental toxicology and the way those methods can be utilized through the military. Softcover.

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All rights reserved. About this PDF file: This new digital representation of the original work has been recomposed from XML files created from the original paper book, not from the original typesetting files. Page breaks are true to the original; line lengths, word breaks, heading styles, and other typesetting-specific formatting, however, cannot be retained, and some typographic errors may have been accidentally inserted. Please use the print version of this publication as the authoritative version for attribution.

The prevalence of endometriosis in women of reproductive age is reported to be 10% (Houston 1984; Olive and Schwartz 1993), and no population-based prevalence data exist for PCOS. With respect to developmental outcomes, population-based data are available regarding the prevalence of birth defects. Approximately 2-3% of infants are born with major birth defects (Holmes 1997). The full impact of prenatal testing on the prevalence of birth defects has not been delineated. , major and minor) are included.

The subcommittee calculated a UEL based on at least one endpoint for each compound, accounting for uncertainties due to deficiencies in the database. Regardless of the quantity of data available, the subcommittee found that considerable scientific judgment was needed to conduct the evaluations. Although these assessments are examples of how to use the evaluative process, they are not complete–largely because the subcommittee was unable to assess thoroughly the conditions of use that result in human exposure.

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