By Amin, Mahul B.; Gast, Patricia; LaPlante, Michelle M.; Marino, Deirdre; Weinberg, Ruth W
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Gleason grade 3 (score 6). A small cluster of neoplastic acini between nonneoplastic glands, indicating Gleason grade 3. FIGURE 2-27. Gleason score 6 (3 + 3). Combination of typical infiltrating, small acinar Gleason pattern 3A with sharply circumscribed cribriform pattern 3C. FIGURE 2-28. Gleason grade 3 (score 6). This focus of minimal (limited) adenocarcinoma consists of a few infiltrating, small acini between nonneoplastic glands, indicating Gleason grade 3. FIGURE 2-31. Gleason grade 3 (score 6).
Gleason score 7 (4 + 3). Most of the cribriform structures in this picture represent Gleason cribriform grade 4; however, some of the intraluminal spaces are evenly and sharply punched indicating a Gleason pattern 3C. FIGURE 2-53. Gleason score 6 (3 + 3). Unusual large gland grade 3 pattern with prominent pseudostratification and tufting, simulating high-grade prostatic intraepithelial neoplasia. A more typical pattern 3A is present on the left side. 32 FIGURE 2-54. Gleason grade 3 (score 6). A: Unusual papillary architecture with enlarged glandular structures is considered a part of pattern 3C in a needle biopsy specimen.
FIGURE 2-45. Gleason grade 3 (score 6). B: (Continued) FIGURE 2-44. Gleason grade 3 (score 6). B: (Continued) FIGURE 2-45. Gleason grade 3 (score 6). A: Needle biopsy showing infiltrating, smallto-medium sized acini with foamy gland appearance. In the absence of fusion, this is indicative of Gleason grade 3. B: Higher FIGURE 2-46. Gleason grade 3 (score 6). This needle biopsy shows infiltration by variably sized glands—some of which appear atrophic and others more cystically dilated. Although no nonneoplastic glands are identified, this widely infiltrative pattern would be indicative of Gleason grade 3.