Read e-book online Ion Channels and Transporters of Epithelia in Health and PDF

By Kirk L. Hamilton, Daniel C Devor

This e-book sheds new gentle at the body structure, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the fundamental mobile versions and services via a compelling medical point of view, addressing elements from the laboratory bench to the bedside. the person chapters, written by means of best scientists and clinicians, discover particular ion channels and transporters situated within the epithelial tissues of the kidney, gut, pancreas and breathing tract, all of which play a very important half in preserving homeostasis. extra subject matters contain the basics of epithelial shipping; mathematical modeling of ion delivery; phone quantity law; membrane protein folding and trafficking; transepithelial shipping services; and finally, a dialogue of shipping proteins as power pharmacological ambitions with a spotlight at the pharmacology of potassium channels.

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1 cell surface expression. Traffic 13:143–156. 1 channel surface expression by inhibiting Nedd4-2 protein. J Biol Chem 288:36841–36854. 525931 Anderson MP, Welsh MJ (1992) Regulation by ATP and ADP of CFTR chloride channels that contain mutant nucleotide-binding domains. Science 257:1701–1704 Anderson MP, Berger HA, Rich DP, Gregory RJ, Smith AE, Welsh MJ (1991a) Nucleoside triphosphates are required to open the CFTR chloride channel. Cell 67:775–784 Anderson MP, Gregory RJ, Thompson S, Souza DW, Paul S, Mulligan RC, Smith AE, Welsh MJ (1991b) Demonstration that CFTR is a chloride channel by alteration of its anion selectivity.

Math Comput 19:297–301 Crabbe J (1961) Stimulation of active sodium transport by the isolated toad bladder with aldosterone in vitro. J Clin Invest 40:2103–2110. 1172/JCI104436 Cuppoletti J, Chakrabarti J, Tewari KP, Malinowska DH (2014) Differentiation between human ClC-2 and CFTR ClÀ channels with pharmacological agents. Am J Physiol Cell Physiol 307: C479–C492. 2014 Curran PF, Solomon AK (1957) Ion and water fluxes in the ileum of rats. J Gen Physiol 41:143–168 Darrow CW (1945) Congenital alkalosis with diarrhea.

Early evidence that this was the case came from duck red blood cells (Haas et al. 1982). In these studies, the duck red cells were exposed to the K+ ionophore valinomycin, thereby increasing membrane K+ permeability such that the membrane voltage was dominated by the K+ reversal potential (EK). Thus, the uptake of Na+ could be studied while bath K+, and therefore membrane voltage, was varied. Under these conditions, the uptake of Na+ was not affected by changes in membrane voltage, demonstrating the electroneutrality of the cotransporter (Haas et al.

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