By Kirk L. Hamilton, Daniel C Devor
This e-book sheds new gentle at the body structure, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the fundamental mobile versions and services via a compelling medical point of view, addressing elements from the laboratory bench to the bedside. the person chapters, written by means of best scientists and clinicians, discover particular ion channels and transporters situated within the epithelial tissues of the kidney, gut, pancreas and breathing tract, all of which play a very important half in preserving homeostasis. extra subject matters contain the basics of epithelial shipping; mathematical modeling of ion delivery; phone quantity law; membrane protein folding and trafficking; transepithelial shipping services; and finally, a dialogue of shipping proteins as power pharmacological ambitions with a spotlight at the pharmacology of potassium channels.
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Extra resources for Ion Channels and Transporters of Epithelia in Health and Disease
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Early evidence that this was the case came from duck red blood cells (Haas et al. 1982). In these studies, the duck red cells were exposed to the K+ ionophore valinomycin, thereby increasing membrane K+ permeability such that the membrane voltage was dominated by the K+ reversal potential (EK). Thus, the uptake of Na+ could be studied while bath K+, and therefore membrane voltage, was varied. Under these conditions, the uptake of Na+ was not affected by changes in membrane voltage, demonstrating the electroneutrality of the cotransporter (Haas et al.