New PDF release: Label-Free Biosensor Methods in Drug Discovery

By Ye Fang

This quantity explores label-free biosensors, valuable partially simply because this know-how bypasses the necessity of labels, journalists, and phone engineering, all of that are universal to categorized strategies yet may well introduce artifacts in assay effects. Addressing a number of basic and sensible features as to the right way to enforce label-free equipment within the drug discovery method, this booklet covers a variety of themes, together with binding kinetics selection, fragment screening, antibody epitope mapping, protein-protein interplay profiling and screening, receptor pathway deconvolution, drug pharmacology profiling and screening, aim identity, drug toxicity evaluation, and actual phenotype profiling and diagnostics according to a number of mobile techniques corresponding to mobilephone adhesion, migration, invasion, an infection, and irritation. As a part of the Methods in Pharmacology and Toxicology sequence, chapters target to supply key element and implementation recommendation to assist with development within the lab.

Practical and thorough, Label-Free Biosensor tools in Drug Discovery offers a brand new road for fast entry to a targeted number of very popular contributions within the field.

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Fang Y (2006) Label-free cell-based assays with optical biosensors in drug discovery. Assay Drug Dev Technol 4:583–595. 583 7. Rocheville M, Jerman JC (2009) 7TM pharmacology measured by label-free: a holistic approach to cell signalling. Curr Opin Pharmacol 9:643–649. 015 8. Rocheville M, Martin J, Jerman J, Kostenis E (2013) Mining the potential of label-free 9. 10. 11. 12. 13. 14. biosensors for seven-transmembrane receptor drug discovery. Prog Mol Biol Transl Sci 115: 123–42. 1016/B978-0-12-394587-7.

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