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By Daniel J. Culkin

Management of Penile Cancer offers a finished and cutting-edge assessment of the key matters particular to the sector of penile melanoma. The sections of the e-book are based to study the final scope of problems with penile melanoma, together with analysis and staging, surgical methods and the therapy of complex ailment. As multidisciplinary care is an essential component of the therapy of penile melanoma, this ebook is exclusive within the inclusion of participating authors from various built-in disciplines, together with urology, radiation oncology, clinical oncology and reconstructive surgery.

Written through famous specialists of their box, Management of Penile Cancer is a distinct and important source within the box of penile melanoma, either for these at present in education and for these already in medical or learn practice.

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Finally, p16INK4a is a tumor suppressor protein known to accumulate in HPV-related tumors in response to Rb inactivation by the viral E7 protein [54]. Overexpression of p16INK4a can be used as a reliable marker for the presence of high-risk HPV DNA and as a tool in the differential diagnostic of penile subtypes. p16INK4a-positive tumors more likely exhibit a basaloid and/or warty morphology, whereas the negative cases tend to correspond to well-differentiated, keratinizing, low-grade variants of penile SCC [55].

74. Cubilla AL, Lloveras B, Alejo M, Clavero O, Chaux A, Kasamatsu E, et al. The basaloid cell is the best tissue marker for human papillomavirus in invasive penile squamous cell carcinoma: a study of 202 cases from Paraguay. Am J Surg Pathol. 2010;34:104–14. J. Fernández et al. 75. Guimerà N, Lloveras B, Lindeman J, Alemany L, van de Sandt MM, Alejo M, et al.

Philadelphia: Lippincott Williams & Wilkins; 2012. p. 1027–42. 6. Velazquez EF, Soskin A, Bock A, Codas R, Barreto JE, Cubilla AL. Positive resection margins in partial penectomies: sites of involvement and proposal of local routes of spread of penile squamous cell carcinoma. Am J Surg Pathol. 2004;28:384–9. 7. Chaux A, Caballero C, Soares F, Guimarães GC, Cunha IW, Reuter V, et al. The prognostic index: a useful pathologic guide for prediction of nodal metastases and survival in penile squamous cell carcinoma.

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