Get Management of Prostate Cancer: A Multidisciplinary Approach PDF

By Michel Bolla, Hendrik van Poppel

This e-book, now in an commonly revised moment variation, offers an exhaustive overview of the cutting-edge within the administration of prostate melanoma, from screening to therapy, with emphasis on a multidisciplinary strategy. The editors are very enthusiastic about the phenomenal new or up to date contributions from the several professional authors.

The beginning chapters tackle simple points together with epidemiology, pathology, biology, genetics, and chemoprevention. The position of person and mass screening is punctiliously appraised, and wide awareness is dedicated to prognosis and scientific work-up by way of lately applied investigations equivalent to multiparametric MRI and choline PET-CT.

The use of lively surveillance is tested intimately. next chapters speak about the various treatments that could be hired: open and minimally invasive, together with robot-assisted, radical prostatectomy, some of the kinds of radiation therapy, high-intensity centred ultrasound, cryotherapy, hormonal manipulations, chemotherapy, specific treatments, and immunotherapy. up to date effects from practice-changing part III randomized scientific trials are incorporated and precise insights are supplied into the translation of effects and the patient’s point of view.

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Example text

The results from epidemiological studies are somewhat inconsistent but, overall, there seems to be a reduced risk [30]. This contradicts the finding that body fatness is a risk factor for prostate cancer. Because the link between diabetes type 2 and prostate cancer is mainly observed in studies from the PSA era, diabetes is known to decrease the serum PSA value, and the association is stronger for lowgrade than for high-grade prostate cancer; it is possible that the association is caused by detection bias.

Body Fatness In its 2014 report on prostate cancer, the World Cancer Research Fund concludes that greater body fatness (marked by BMI, waist circumference and waist-hip ratio) is probably a cause of advanced prostate cancer. In a meta-analysis of 23 studies (N = 11,149) on advanced prostate cancer, a statistically significant 8 % increased risk was found per 5 kg/m2 increase in body mass index (BMI) [36]. 1 unit increase. It is not entirely clear what the mechanism is behind this association. Obesity influences the levels of quite a few hormones and growth factors such as insulin and leptin, which can promote the growth of cancer cells.

Rather than high-penetrance genes may cause a The G84E (rs138213197) mutation in HOXB13 clustering of patients in families. 5–7 for cally determined but merely the result of prostate cancer [21, 25]. More and more clinical increased awareness and PSA testing of men in genetics centres around the world are starting to such families. The finding that prostate cancer test for these genes in men at increased prostate patients in these families have a better prognosis cancer risk. than patients from the general population supports this alternative explanation [12].

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