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By Günther Schneider M.D., Luigi Grazioli M.D., Sanjay Saini M.D. (auth.), Günther Schneider M.D., Luigi Grazioli M.D., Sanjay Saini M.D. (eds.)

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38. Knopp et al. Assessment of Gadohenate Dimeglumine (Gd-BOPTA) for MR Angiography: Phase I Studies. Invest. Radio!. 2002; In press. 39. Kirchin MA, Pirovano G, Venetianer C, Spinazzi A. Safety assessment of gadobenate dimeglumine (Multihance,): extended clinical experience from phase I studies to post-marketing surveillance. J Magn Reson Imaging 2001; 14:281-294. 40. Kroencke TJ, Wasser MN, Pattynama PMT et al. Contrast-enhanced magnetic resonance angiography of the abdominal aorta and renal arteries with gadobenate dimeglumine.

Invest Radiol2002; 37:135-145. 12. Coffin CM, Diche T, Mahfouz A, Alexandre M, Caseiro-Alves F, Rahmouni A, Vasile N, Mathieu D .. Benign and malignant hepatocellular tumors : evaluation of tumoral enhancement after mangafodipir trisodium injection on MR imaging. Eur Radiol1999; 9:444-449. 13. Colosimo C. Ruscalleda J, Korves M, La Feria R, Wool C, Pianezzola P, Kirchin MA. Detection of intracranial metastases: a multi-center, intra-patient comparison of gadobenate dimeglumine-enhanced MRI with routinely used contrast agents at equal dose.

A useful sequence is 2D or 3D spoiled GRE with a matrix size of 512/256 X 512 (Fig. 3). Since liver enhancement in patients with cirrhosis is limited with mangafodipir trisodium [69), liver lesion detection on mangafodipir-enhanced MR imaging is primarily effective in patients with normal liver parenchyma. In these patients, non-hepatocellular focal lesions generally appear hypointense to the normal liver on post-contrast Tl-weighted images [5, 102). Several studies have shown a benefit for liver lesion detection with mangafodipirenhanced hepatic MR imaging compared with unenhanced MR imaging [4, 5, 20, 29, 101, 102).

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