Download e-book for iPad: Neurogenetics of psychiatric disorders by Akira Sawa, Melvin G. McIinnis

By Akira Sawa, Melvin G. McIinnis

Translating bench-based examine into powerful medical perform, this resource presents a transparent realizing of the neurobiology and neurogenetics of psychiatric issues, the genes chargeable for particular psychiatric problems, and the results of genetic roots and underlying biology at the improvement of recent diagnostic ways and remedy treatments for various psychiatric stipulations.

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189. Johnson MJ, Wallace DC, Ferris SD, et al. Radiation of human mitochondria DNA types analyzed by restriction endonuclease cleavage patterns. J Mol Evol 1983; 19: 255–271. 190. Chen YS, Torroni A, Excoffier L, et al. Analysis of mtDNA variation in African populations reveals the most ancient of all human continent-specific haplogroups. Am J Hum Genet 1995; 57:133–149. 191. Cassarino DS, Bennett JP Jr. An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology protective nuclear responses and cell death in neurodegeneration.

The tRNA(Gln) 4336 mitochondrial DNA variant is not a high penetrance mutation which predisposes to dementia before the age of 75 years. J Med Genet 1996; 33:1002–1006. 210. Mayr-Wohlfart U, Rodel G, Henneberg A. Mitochondrial tRNA(Gln) and tRNA(Thr) gene variants in Parkinson’s disease. Eur J Med Res 1997; 2:111–1113. 211. Zsurka G, Kalman J, Csaszar A, et al. No mitochondrial haplotype was found to increase risk for Alzheimer’s disease. Biol Psychiatry 1998; 44:371–373. 212. Chinnery PF, Taylor GA, Howell N, et al.

Chapman J, Korczyn AD, Karussis DM, et al. The effects of APOE genotype on age at onset and progression of neurodegenerative diseases. Neurology 2001; 57:1482–1485. 51. Poirier J. Apolipoprotein E and Alzheimer’s disease. A role in amyloid catabolism. Ann N Y Acad Sci 2000; 924:81–90. 52. Pericak-Vance MA, Bass ML, Yamaoka LH, et al. Complete genomic screen in lateonset familial Alzheimer’s disease. Neurobiol Aging 1998; 19:S39–S42. 53. Rogaeva E, Premkumar S, Song Y, et al. Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity.

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