By Giorgio Cavallini, Gianni Paulis
This booklet goals to supply experts and practitioners with a competent resource of data on all points of Peyronie’s affliction, that's too frequently nonetheless thought of a mysterious . the focal point is specifically on these features of the disorder which are so much hotly debated, together with etiology, danger components, nosology, usual historical past and clinical treatment. transparent counsel is usually supplied on surgical recommendations, with clarification of why and while to use plication surgical procedure, corporoplasty and plaque surgical procedure and the easiest method of complex situations. all through, strenuous efforts were made to make sure readability and ease of expression and simplicity of session. whereas transparent foreign instructions are missing, this has allowed the authors to commit a lot house to non-public principles, conveying the attention-grabbing and infrequently conflicting nature of this box of drugs and, expectantly, stimulating additional learn.
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Extra resources for Peyronie’s Disease: A Comprehensive Guide
2 Status of the Current Knowledge Peyronie’s disease is a connective tissue disorder of the tunica albuginea. This phenomenon is characterized by changes in the collagen and elastin metabolism and composition of the tunica albuginea . The underlying physiopathological mechanism is still is poorly understood. However, it is well known that PD is an inflammatory process of the tunica albuginea characterized by an increase in and disorganization of collagen fibers, persistent fibrin deposition within the tissue, and elastin fragmentation .
The evaluation of patients at follow-up was carried out with the following simple assessments: palpation of the penile nodule, presence of pain and the presence of the curvature. The same authors (1970), in another study, reported that none of the 21 patients with untreated PD experienced a worsening of their condition . Obviously, it must be considered that in 1968 the penile colour Doppler ultrasound study was not available. 7 %)) and worsened (4 cases (21 %)) . The classification was based only on a consideration of the patients’ symptoms and physical findings at follow-up attendances: deformity of the penis on erection, lump in the penis, penile pain during erection, difficulty in performing sexual intercourse, proximal distension and distal laxity of the erect penis.
It is considered as a profibrotic cytochine that is involved in cellular proliferation and/or differentiation, an essential system in the pathogenesis of fibrotic disorder. The TGF-β1 injection is able to induce chronic inflammation and fibrosis in the tunica tissue over time. It is due to its ability to induce its own production that it may be the key to the development of the scarring and fibrosis into chronic, progressive condition . Moreover, El-Sakka demonstrated that the PD-like plaque induced by the TGF-β1 injection was reduced by colchicine, a collagenase and myofibroblasts inhibitor drug .