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Additional resources for Pharmacology of the Coronary Circulation. Volume 10
It was first suggested as a coronary vasodilator in 1959 ( M e n g e and Kadatz, 1959; Kadatz, 1959). Experimental work has shown that Persantin 48 PHYSIOLOGY A N D P H A R M A C O L O G Y produces a significant increase in the volume rate o f coronary blood flow, is twice as active as and has a more prolonged action than papaverine. T h e increase o f blood flow in the coronary vessels is, however, accompanied b y increase in the quantity o f oxygen absorbed b y the heart. Slight reduction o f arterial pressure with reduction in the minute volume o f the heart has been observed.
Novocain has a very g o o d effect in experimental myocardial infarct. R y z h o v a (1956, 1961) found that novocain produced considerable improvement in the condition o f the animal and rendered the E C G almost completely normal in experimental myocardial infarct produced b y division o f one o f the coronary arteries or b y the injection o f a large dose o f adrenaline. It is evident from these various observations that the effect o f novocain on the blood supply to the heart differs very considerably under different experimental conditions.
1938) found that histamine dilated the coronary vessels in experiments on the isolated fibrillating heart. Kountz et al. (1934) reported that the reaction o f the still living human heart to histamine varied greatly. These authors constantly observed dilatation o f the coronary vessels in the beating heart but this effect was only seen in the arrested heart when the cardiac arrest had been produced by perfusion with a solution o f low p H . , 1940). T h e histamine effect is o f very short duration (not more than 3 or 4 m i n ) .