By E. Christophers, C. Schubert, M. Goos (auth.), Professor Malcolm W. Greaves M.D., Ph.D., F.R.C.P., Professor Sam Shuster M.D., F.R.C.P. (eds.)
The fresh curiosity within the pharmacology of the surface and the therapy of its ailments has take place for 2 purposes. the 1st is a realisation that many points of pharmacology could be studied as simply in human epidermis, the place they are extra appropriate to human body structure and ailments, as in animal versions. Examples of this are the motion of assorted vasoactive brokers and the isolation of mediators of irritation after UV irradiation and antigen-induced dermatitis. the second one cause is the fortuitous realisation pharmacological method of the remedy of epidermis illness needn't consistently look forward to the whole elucidation of etiology and mechanism. for instance, while the argument persevered unresolved to whether the pilo-sebaceous an infection which constitutes pimples used to be because of a blocked duct or to an easy bring up in sebum construction, 13-cis-retinoic acid used to be came across really accidentally absolutely to ablate the illness; back, while cyclosporin, clean from its triumphs in organ transplantation, has been came across in a position to suppress the rash of psoriasis, it has resuscitated the talk on etiology. we're hence coming into a brand new period within which the pharmacology and scientific pharmacology of epidermis are being studied as a desirable new manner of exploring questions of human body structure and pharmacology in addition to a tremendous step within the improvement and research of recent medicinal drugs, use of so that it will increase illness keep an eye on and while support to outline pathological mechanisms.
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Additional resources for Pharmacology of the Skin I: Pharmacology of Skin Systems Autocoids in Normal and Inflamed Skin
9) Besides these granule-containing Langerhans cells there are so-called indeterminate cells in the epidermis. For a long time they were thought to be a different dendritic cell type (for review see WOLFF 1972). Probably these cells are related to Langerhans cells and to interdigitating cells of the lymphatic tissue. Except for the Birbeck granule, these cells are isomorphous and form part of a universal system including thymus, spleen, lymph node, tonsil and stratified epithelia. It may well be that indeterminate cells of the epidermis and interdigitating cells of lymphoid organs turn out to be identical cell types.
MTP Press, Lancaster, pp 43-61 Chopra DP, Flaxman BA (1972) Human epidermal cell cycle in vitro. Br J DermatoI87:1317 Christophers E (1970) Eine neue Methode zur Darstellung des stratum corneum. Arch Klin Exp Derm 237:717-721 Christophers E (1971 a) Die epiderm ale Columniirstruktur. Z Zellforsch 114:441-450 Christophers E (1971 b) Cellular architecture of the stratum corneum. J Invest Dermatol 56:165-169 Christophers E (1972a) Correlation between columns formation, thickness and rate of new cell production in guinea pig epidermis.
With data given for Ts (or even TM or Td the turnover or a tissue compartment of the entire organ may be calculated provided the number of cells present in this compartment is known. Therefore rigorous quantification of epidermal cellularity applying Abercombie's correction for tissue geometry is needed (LAURENCE and CHRISTOPHERS 1976). 6 basal cells in mitosis per thousand cells. The mitotic process lasts around 90 min. Between 3% and 5% of cells are in DNA synthesis and the length of the S phase tends to be around 7 h.