By Edward W. Flückiger, Emilio del Pozo, Klaus von Werder (auth.)
Lactogenic hormone job was once first saw in bovine pituitary extracts by means of Stricker and Griiter in 1928, operating in Bouin's laboratory in Strasbourg. due to the fact that that point prolactin has been proven to exist in anterior pituitary extracts of virtually all vertebrate species investigated. even supposing its biology used to be commonly studied in lots of mammalian species, the lifestyles of prolactin within the human used to be in general doubted, regardless of the optimistic facts produced by means of such researchers as Pasteels. this may partially be defined by way of the truth that human progress hormone remoted in 1961, is itself a effective lactogen, not like nonprimate progress hormones, and is found in the traditional human pituitary in a lot larger quantities than prolactin. accordingly there has been a lag of approximately 10 years till prolactin used to be unanimously accredited as a hormone of the human pituitary, break away human development hormone. In 1970 new bioassay ideas authorised the demonstration of prolactin bioactivity within the serum of postpartum girls and galactorrhea sufferers, and chromatographic tools resulted in the isolation and purification of human prolactin permitting the institution of a selected radioimmunoassay for this hormone. This opened the line to the knowledge of prolactin body structure and pathophysiology within the human, which has revolutionized scientific neuroendocrinology and reproductive endocrinology. quite hyperprolactinemia has grew to become out to be some of the most universal endocrine syndromes.
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Extra info for Prolactin: Physiology, Pharmacology and Clinical Findings
The authors suggested that both IX-ergocryptine and ergotamine, which are ca. 50 and> 100 times more potent vasoconstrictor agents (IX-agonists) than bromocriptine (Fliickiger 1976), reduced capillary blood supply to the tumors and thereby decreased tumor growth and prolactin release. The reason why these tumors are not sensitive to the action ofbromocriptine is unexplained. A connection seems to exist between the phenomenon of desensitization and estrogens of DA receptors of normal prolactin cells (Labrie et al.
C R Soc Bioi (paris) 150:173-175 Aumiiller G (1979) Prostate gland and seminal vesicles. Springer, Berlin Heidelberg New York Bach NJ, Kornfeld EC, 10nes ND, Chaney MO, Dorman DE, Paschal lW, Clemens JA, Smalstig EB (1980) Bicyclic and tricyclic ergoline partial structures. Rigid 3-(2-Aminoethyl)pyrroles and 3- and 4(2-Aminoethyl)pyrazoles as dopamine agonists. 1 Med Chern 23:481-491 Barkey Rl, Shani 1, Amit T, Barzilai D (1977) Characterization of the specific binding of prolactin to binding sites in the seminal vesicle of the rat.
1977) (see Sect. 5, p. 40). Besides estrogens testosterone also, but not its 5areduced metabolite, may stimulate prolactin secretion in castrated rats, probably after conversion to estrogen (Martini et al. 1978). Recently, the nonuterotrophic metabolite of estradiol, 2-hydroxy-estrone, a catechol-estrogen, was claimed to decrease prolactin levels of postmenopausal, estrogen-primed women to less than 25% of the initial value (Schinfeld et al. 1980). This was an unexpected effect which was not observed in nonestrogenized postmenopausal women, and which had not been observed in an earlier, but similarly conducted study (Adashi et al.